GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs6684514 | 1 | rs12117951 | chr1:156305286 | CCT3 | chr1:156278752-156308195:- | -0.11 | -3.61 | 0.000322 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12118238 | chr1:156235221 | BGLAP | chr1:156182784-156213112:+ | 0.19 | 4.92 | 1.01E-6 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12118238 | chr1:156235221 | C1orf85 | chr1:156259882-156265449:- | -0.12 | -3.47 | 0.000532 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12118238 | chr1:156235221 | CCT3 | chr1:156278752-156308195:- | -0.11 | -3.37 | 0.000765 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs12118297 | 1 | rs12118297 | chr1:87779217 | HS2ST1 | chr1:87380335-87575680:+ | 0.13 | 3.52 | 0.000456 | Breast cancer |
| BRCA | cis | rs17401966 | 1 | rs12118323 | chr1:10469641 | PGD | chr1:10459085-10480200:+ | 0.22 | 6.29 | 4.5E-10 | Hepatocellular carcinoma |
| BRCA | cis | rs17030613 | 1 | rs12120956 | chr1:113202571 | ST7L | chr1:113066142-113162405:- | 0.56 | 11.75 | 4.59E-30 | Diastolic blood pressure;Blood pressure |
| BRCA | cis | rs6684514 | 1 | rs12121805 | chr1:156257876 | BGLAP | chr1:156182784-156213112:+ | 0.21 | 5.54 | 3.71E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs6684514 | 1 | rs12121805 | chr1:156257876 | C1orf85 | chr1:156259882-156265449:- | -0.11 | -3.52 | 0.000457 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs12122100 | 1 | rs12122100 | chr1:146508934 | LOC728989 | chr1:146490895-146514599:- | -0.13 | -3.59 | 0.000341 | HIV-1 control |
| BRCA | cis | rs6684514 | 1 | rs12122180 | chr1:156244559 | BGLAP | chr1:156182784-156213112:+ | 0.2 | 5.31 | 1.31E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BRCA | cis | rs4925540 | 1 | rs12122290 | chr1:247215810 | ZNF670 | chr1:247200087-247242069:- | -0.25 | -7.03 | 3.75E-12 | Response to taxane treatment (docetaxel) |
| BRCA | cis | rs17030613 | 1 | rs12126971 | chr1:113231286 | ST7L | chr1:113066142-113162405:- | 0.54 | 11.43 | 1.26E-28 | Diastolic blood pressure;Blood pressure |
| BRCA | cis | rs11799420 | 1 | rs12128536 | chr1:171674607 | VAMP4 | chr1:171669298-171711214:- | 0.2 | 5.67 | 1.79E-8 | Hippocampal atrophy |
| BRCA | cis | rs17401966 | 1 | rs12129035 | chr1:10291166 | PGD | chr1:10459085-10480200:+ | 0.19 | 5.55 | 3.59E-8 | Hepatocellular carcinoma |